李瑞金，山西大学环境科学研究所教授，环境科学专业博士，博士生导师，研究方向为环境污染与健康。长期从事典型大气污染物（SO2和PM2.5）污染及毒理学研究，特别在大气PM2.5成分分析、源解析及风险评估、PM2.5毒理效应及机制研究方面取得了突出成绩，积累了丰富研究经验，掌握了GC-MS、HPLC-MS、环境毒理学、分子生物学及组学研究技术。有博士后工作经历及赴美国加州大学和香港浸会大学访问合作的经历。拥有环境影响评价上岗证，并参与过建设项目环境影响评价报告书的编写工作，是山西省环境损害司法鉴定中心成员。主持了关于环境污染特征及毒理学效应的国家及省市级项目10余项；参与了细颗粒物国家重大研究计划重点项目和集成项目的研究工作，已发表科研论文89篇，其中58篇为SCI期刊论文。获得2019年度山西省科学技术奖（自然科学类）二等奖（排名第四）；获得2019年度山西省高等学校优秀成果奖（科学技术）二等奖（排名第一）及2018年度山西省科学技术奖（自然科学类）三等奖（排名第一），获2009年度山西省科学技术奖（自然科学类）一等奖（排名第五）。2014年获得中国环境科学学会第十届优秀环境科技工作者奖。参编《环境毒理学》等教材和著作7部。多次在全国环境和健康会议上做报告。

主要科研成果：

一、主要学术论文

发表学术论文89，其中SCI核心期刊收录论文58篇（第一作者20篇，通讯作者11篇）。

代表性文章：

1.Bai L, Zhao Y, Zhao L, Zhang M, Cai Z, Yung KKL, Dong C*, Li R*. Ambient air PM2.5 exposure induces heart injury and cardiac hypertrophy in rats through regulation of miR-208a/b, α/β-MHC, and GATA4. Environmental Toxicology and Pharmacology, 2021, July, 85, 103653.

2.Zhao C, Xie P, Yong T, Huang W, Liu J, Wu D, Ji F, Li M, Zhang D, Li R, Dong C, Ma J, Dong Z, Liu S, Cai Z*. Airborne fine particulate matter induces cognitive and emotional disorders in offspring mice exposed during pregnancy. Science Bulletin, 2021, 66(6):578-591.

3.Song Y, Qi Z, Zhang Y, Wei J, Liao X, Li R, Dong C, Zhu L, Yang Z, Cai Z*. Effects of exposure to ambient fine particulate matter on the heart of diet-induced obesity mouse model. Sci Total Environ. 2020 Aug 25;732:139304.

4.Song Y, Zhao L, Qi Z, Zhang Y, Cao G, Li R, Zhu L, Yang Z, Dong C, Cai Z*. Application of a real-ambient fine particulate matter exposure system on different animal models. Journal of Environmental Sciences, 2021, 105: 64-70.

5.Li R, Zhao Y, Shi J, Zhao C, Xie P, Huang W, Yong T, Cai Z*. Effects of PM2.5 exposure in utero on heart injury, histone acetylation and GATA4 expression in offspring mice. Chemosphere, 2020年5月,256,127133

6.Zhao Y, Mao W, Pang L, Li R*, Li S*. Influence of Phragmites communis and Zizania aquatica on rhizosphere soil enzyme activity and bacterial community structure in a surface flow constructed wetlands treating secondary domestic effluent in China. Environ. Sci. Pollut. Res., 2020, May,27:26141–26152.

7.Fu P, Bai L, Cai Z, Li R*, Yung KKL*. Fine particulate matter aggravates intestinal and brain injury and affects bacterial community structure of intestine and feces in Alzheimer's disease transgenic mice. Ecotoxicol Environ Saf. 2020, 192, 110325

8.Chen YJ, Zhang YH, Chen YY, Lu Y, Li R, Dong C, Qi Z, Liu G, Chen Z*, Cai Z*.GC-MS/MS analysis for source identification of emerging POPs in PM2.5. Ecotoxicol Environ Saf. 2020,193, 110368

9.Zhang M, Li Z, Xu M, Yue J, Cai Z, Yung KKL*, Li R*. Pollution characteristics, source apportionment and health risks assessment of fine particulate matter during a typical winter and summer time period in urban Taiyuan, China. Human and Ecological Risk Assessment: An International Journal,2020,26(10):2737-2750.

10.Song Y, Zhang Y, Li R, Chen W, Chung CKA, Cai Z*. The cellular effects of PM2.5 collected in Chinese Taiyuan and Guangzhou and their associations with polycyclic aromatic hydrocarbons (PAHs), nitro-PAHs and hydroxy-PAHs. Ecotoxicol Environ Saf. 2020,191:110225.

11.Zhang Y, Song Y, Wu J, Li R, Hu D, Lin Z, Cai Z*. A magnetic covalent organic framework as an adsorbent and a new matrix for enrichment and rapid determination of PAHs and their derivatives in PM2.5 by surface-assisted laser desorption/ionization-time of flight-mass spectrometry. Chem Commun (Camb),2019, 55(26):3745-3748. doi: 10.1039/c9cc00384c.

12.Zhang Y, Chen Y, Li R, Chen W, Song Y, Hu D, Cai Z. Determination of PM2.5-bound polyaromatic hydrocarbons and their hydroxylated derivatives by atmospheric pressure gas chromatography-tandem mass spectrometry. Talanta, 2019,195:757-763. doi: 10.1016/j.talanta.2018.12.006.

13.Wang Z, Gao S, Xie J*, Li R. Identification of multiple dysregulated metabolic pathways by GCMS-based profiling of liver tissue in mice with OVA-induced asthma

exposed to PM2.5. Chemosphere, 2019, 234,277-286.

14.Zhao C, Zhu L, Li R, Wang H, Cai Z*. Omics approach reveals metabolic disorders associated with the cytotoxicity of airborne particulate matter in human lung carcinoma cells. Environmental Pollution, 2019, 246, 45-52.

15.Wang Z, Gao S, Xie J*, Li R. Identification of multiple dysregulated metabolic pathways by GC-MS-based profiling of lung tissue in mice with PM2.5-induced asthma. Chemosphere, 2019, 220,1-10.

16.Wang Y, Zhang M, Li Z, Yue J, Xu M, Zhang Y, Yung KKL*, Li R*. Fine particulate matter induces mitochondrial dysfunction and oxidative stress in human SH-SY5Y cells. Chemosphere, 2019, 218,577-588.

17.Zhao L, Zhang L, Chen M, Dong C, Li R*, Cai Z*. Effects of ambient atmospheric PM2.5, 1-Nitropyrene and 9-Nitroanthracene on DNA damage and oxidative stress in hearts of rats. Cardiovascular Toxicology, 2019,19,178-190.

18.Wang Y, Zhang M, Zhao L, Zhang W, Zhao T, Chu J, Qiu Y, Gong H, Li R*. Effects of tetrabromobisphenol A on maize (Zea mays L.) physiological indexes, soil enzyme activity, and soil microbial biomass. Ecotoxicology, 2019, 28, 1-12.

19.Chen Y, Chen Y, Zhang Y, Li R, Chen W, Yan S, Qi Z, Chen Z, Cai Z*. Determination of HFRs and OPFRs in PM2.5 by ultrasonic-assisted extraction combined with multi-segment column purification and GC-MS/MS. Talanta, 2019,194,320-328.

20.Qi Z, Song Y, Ding Q, Liao X, Li R, Liu G, Tsang S*, Cai Z*. Water soluble and insoluble components of PM2.5 and their functional cardiotoxicities on neonatal rat cardiomyocytes in vitro. Ecotoxicol Environ Saf. 2018, 168:378-387.

21.Song Y, Li R, Zhang Y, Wei J, Chen W, Chung CK.A, Cai Z*. Mass spectrometry-based metabolomics reveals the mechanism of ambient fine particulate matter and its components on energy metabolic reprogramming in BEAS-2B cells. Science of The Total Environment. 2019, 651, 3139-3150.

22.Li R, Zhang M, Wang Y, Yung KKL, Su R, Li Z., Zhao L, Dong C*, Cai Z*. Effects of atmospheric PM2.5 subchronic exposure on fibrosis, inflammation, endoplasmic reticulum stress and apoptosis in livers of rats. Toxicology Research, 2018,7, 271-282.

23.Zhang Y, Li R, Fang J, Wang C, Cai Z*. Simultaneous Determination of Eighteen Nitro-Polyaromatic Hydrocarbons in PM2.5 by Atmospheric Pressure Gas Chromatography-Tandem Mass Spectrometry. Chemosphere. 2018,198, 303-310.

24.Lu W, Li R, Shuang S, Dong C*, Cai Z*. Reduced carbon nanodots as a novel substrate for direct analysis of bisphenol analogs in surface assisted laser desorption/ionization time of flight mass spectrometry. Talanta, 2018, 190,89-94.

25.Zhang Y, Yang Z, Chen Y, Li R, Geng H, Dong W, Cai Z*, Dong C*. Fine chalk dust induces inflammatory response via p38 and ERK MAPK pathway in rat lung. Environ Sci Pollut Res Int. 2018 Jan;25(2):1742-1751.

26.Jin X, Su R, Li R, Cheng L, Li Z*. Crucial role of pro-inflammatory cytokines from respiratory tract upon PM2.5 exposure in causing the BMSCs differentiation in cells and animals. Oncotarget, 2017, 9(2):1745-1759.

27.Jin X, Chen M, Li R, An Q, Song L, Zhao Y, Xiao H, Cheng L, Li Z*. Progression and inflammation of human myeloid leukemia induced by ambient PM2.5 exposure. Archives of Toxicology. 2016, 90(8), 1929-1938

28.Li R, Zhao L, Zhang L, Chen M, Shi J, Dong C*, Cai Z*. Effects of ambient PM2.5 and 9-nitroanthracene on DNA damage and repair, oxidative stress and metabolic enzymes in lungs of rats. Toxicology Research, 2017, 6(5):654-663.

29.Li R*, Zhao L, Zhang L, Tong J, Yan Y, Xu C. Fine particulate matter and sulfur dioxide co-exposures induce rat lung pathological injury and inflammatory responses via TLR4/p38/NF-κB pathway. International Journal of Toxicology, 2017, 36(2):165-173.

30.Li R, Zhao L, Zhang L, Chen M, Dong C*, Cai Z*. DNA damage and repair, oxidative stress and metabolism biomarker responses in lungs of rats exposed to ambient atmospheric 1-nitropyrene. Environmental Toxicology and Pharmacology, 2017, 54, 14-20.

31.Yang Z, Chen Y, Zhang Y, Li R*, Dong C*. The role of pro-/anti-inflammation imbalance in Aβ42 accumulation of rat brain co-exposed to fine particle matter and sulfur dioxide. Toxicol Mech Methods. 2017, 27(8):568-574

32.Jin X, Su R, Li R, Song L, Chen M, Cheng L, Li Z*. Amelioration of particulate matter-induced oxidative damage by vitamin c and quercetin in human bronchial epithelial cells. Chemosphere 2016,144: 459-466.

33.Lu W, Li Y, Li R, Shuang S, Dong C*, Cai Z*. Facile Synthesis of N-Doped Carbon Dots as a New Matrix for Detection of Hydroxy-Polycyclic Aromatic Hydrocarbons by Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry. ACS Appl. Mater. Interfaces 2016, 8: 12976-12984.

34.Li R, Kou X, Geng H, Xie J, Yang Z, Zhang Y, Cai Z *, Dong C*. Effect of ambient PM2.5 on lung mitochondrial damage and fusion/fission gene expression in rats. Chemical Research in Toxicology, 2015, 28(3): 408-418.

35.Li R, Kou X, Xie L, Cheng F*, Geng H*. Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity and expression of c-fos and c-jun in lungs of rats. Environmental Science and Pollution Research, 2015, Dec;22(24):20167-76.

36.Li R, Kou X, Geng H, Xie J, Tian J, Cai Z*, Dong C*. Mitochondrial damage: an important mechanism of ambient PM2.5 exposure-induced acute heart injury of in rats. Journal of Hazardous Materials 2015, 287C: 392-401

37.Zhang J, Zhang L, Li R, Hu D, Ma N, Shuang S, Cai Z*, Dong C*. Magnetic graphene composites as both adsorbent for sample enrichment and MALDI-TOF MS matrix for the detection of nitropolycyclic aromatic hydrocarbons in PM. Analyst 2015, 140(5): 1711-6.

38.Ma N, Bian W, Li R, Geng H, Zhang J, Dong C, Shuang S*,Cai Z*. Efficient quantitative analysis of nitro-polycyclic aromatic hydrocarbons in PM2.5 samples by MALDI TOF MS with graphene as matrix. Analytical Methods, 2015, 7: 3967-3971.

39.Zhang Y, Yang Z, Li R, Geng H*, Dong C*. Investigation of fine chalk dust particles’ chemical compositions and toxicities on alveolar macrophages in vitro. Chemosphere 2015, 120: 500-506.

40.Zhang Y, Yang Z, Zhang Q, Li R, Geng H*, Dong C*. Chemical compositions and effects on chemiluminescence of AMs in vitro of chalk dusts. Chinese Chemical Letters, 2015, 26(1): 157–159.

41.Zhang Y, Yang Z, Feng Y, Li R, Zhang Q, Geng H*, Dong C*. Effects of coarse chalk dust particles (2.5–10 μm) on respiratory burst and oxidative stress in alveolar macrophages. Environ Sci Pollut Res, 2015, 22: 12450-12457.

42. Ma N, Zhang L, Li R, Zhou Y, Cai Z, Dong C, Shuang S. Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD. Anal. Methods, 2014, 6: 6736-6744.

43.Li R, Kou X, Tian J, Meng Z, Cai Z, Cheng F*, Dong C*. Effect of sulfur dioxide on inflammatory and immune regulation in asthmatic rats. Chemosphere 2014, 122: 296-304.

44.Li R, Kou X, Geng H, Dong C*, Cai Z*. Pollution characteristics of ambient PM2.5-bound PAHs and NPAHs during winter time in Taiyuan. Chinese Chemical Letters 2014, 25: 663-666.

45.Li R*, Tian J, Li W, Cheng F, Gao G. Effect of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine on oxidative stress and gene expression of c-fos, c-jun, p16 and Rb in rat colons and protective role of seabuckthorn seed oil. J. Environ. Sci. Heal. B. 2014, 49: 279-289.

46.Li R, Zhou Y, Ren G, Wang L*, Zou E. Effects of cadmium alone and in combination with low molecular weight chitosan on metallothionein, glutathione-S-transferase, acid phosphatase, and ATPase of freshwater crab Sinopotamon yangtsekiense. Environ. Toxicol. 2014, 29(3): 298-309.

47.Wu Y, Zhou H, Wu K, Lee S, Li R, Liu X*. PTEN phosphorylation and nuclear export mediate free fatty acid-induced oxidative stress. Antioxid. Redox. Signal. 2014, 20(9): 1382-1395.

48.Li R*, Tian J, Li W, Xie J. Effects of 2-amino-1-methyl-6-phenylimidazo [4, 5-b] pyridine (PhIP) on histopathology, oxidative stress, and expression of c-fos, c-jun and p16 in rat stomachs. Food Chem. Toxicol. 2013, 55: 182-191.

49.Li R, Zhou Y, Wang L*, Ren G. Low-molecular-weight-chitosan ameliorates cadmium-induced toxicity in the freshwater crab, Sinopotamon yangtsekiense. Ecotox. Environ. Safe. 2011, 74(5): 1164-1170.

50.Li R, Zhou Y, Ji J, Wang L*. Oxidative damages by cadmium and the protective effects of low-molecular-weight chitosan in the freshwater crab (Sinopotamon yangtsekiense Bott 1967). Aquacul. Res. 2011, 42(4): 506 -515.

51.Li R, Yuan C, Dong C, Shuang S*, Choi M F*. In vivo antioxidative effect of isoquercitrin on cadmium-induced oxidative damage to mouse liver and kidney. Naunyn-Schmied. Arch. Pharmacol. 2011, 383(5): 437-445.

52.Li J, Li R, Meng Z*. Sulfur dioxide upregulates the aortic nitric oxide pathway in rats. European Journal of Pharmacology. 2010,645: 143-150.

53.Xie J, Li R, Meng Z*. Effects of sulfur dioxide on expressions of p53,bax and bcl-2 in lungs of asthmatic rats. Inhal. Toxicol. 2009, 21(11): 952-957.

54.Li R, Meng Z*, Xie J. Effects of Sulfur Dioxide on the Expressions of EGF, EGFR, and COX-2 in Airway of Asthmatic Rats. Arch. Environ. Contam. Toxicol. 2008, 54: 748-757.

55.Li R, Meng Z*, Xie J. Effects of sulfur dioxide on the expressions of MUC5AC and ICAM-1 in airway of asthmatic rats. Regul. Toxicol. Pharmacol. 2007, 48(3): 284-291.

56.Li R, Meng Z*, Xie J. Effects of sulfur dioxide derivatives on four asthma-related gene expressions in human bronchial epithelial cells. Toxicol. Lett. 2007, 175(1-3): 71-81.

57.Li R, Meng Z*.Effects of SO2 derivatives on expressions of MUC5AC and IL-13 in human bronchial epithelial cells. Arch. Toxicol. 2007, 81(12): 867-874.

58.Meng Z*, Li R, Zhang X. Levels of sulfite in three organs from mice exposed to sulfur dioxide. Inha.l Toxicol. 2005, 17(6): 309-13.

59.白丽荣, 谭子康, 龚航远, 耿红, 董川, 李瑞金*. 大气PM2.5全身系统暴露对大鼠多脏器病理、氧化应激指标和炎症因子的影响. 生态毒理学报, 2020, 15(6):900-905.

60.王影，张玫，赵利芳，张薇，赵婷，储靖璇，邱琰皓，龚航远，李瑞金*. 四溴双酚A对玉米种子发芽和根伸长及氧化损伤指标的影响.环境与健康杂志，2018,7:590-593.

61.张玫，赵利芳，王影，苏瑞军，刘晓娜，李卓玉，李瑞金*. 大气细颗粒物亚慢性染毒对大鼠肺内质网应激相关因子表达的影响.环境科学学报，2017,37(11):4444-4448.

62.赵利芳, 张书源, 佟金龙, 闫宇超, 徐冲, 孟紫强, 李瑞金*. PM2.5和SO2复合暴露对大鼠心脏病理学及炎症因子表达的影响. 环境科学学报, 2017,37(5): 2006-2011.

63.李瑞金*，张玫，赵利芳，王影，苏瑞军，刘小娜，李卓玉. 太原市冬夏季PM2.5亚慢性染毒对大鼠肺炎症因子和CK-18表达的影响. 山西大学学报, 2017,40(3):622-627.

64.李瑞金, 赵利芳, 王振涛, 翟苗苗, 白云龙, 张全喜, 李君灵.* PM2.5对运动大鼠肺氧化损伤和炎症反应相关指标的影响.环境与健康杂志，2016,33(2):175-178.

65.李瑞金,耿红,蔡宗苇,宋沼鹏,徐丽敏,陈洁,陈鸣晖.太原市冬季PM2.5中多环芳烃、硝基多环芳烃、SO42-和NO3-的污染特征. 建材技术与应用, 2014, 177(1):13-15.二、主持或参与的主要课题

1.山西省科技厅社会发展项目：山西典型地区大气细颗粒物中新型污染物分析及溯源研究，2019.12-2021.12，10万元，在研，主持

2.山西省自然科学基金项目：SIRT3在PM2.5致心脏线粒体动力学失衡中的作用机制研究(201801D121260)，2018.12-2020.12，5万元，在研，主持

3.2019年1331太原市大气细颗粒物污染特征及毒理学效应研究（2019KJ003），2019.12-2020.12，5万元，结题，主持

4.2019横向项目：太原市某垃圾填埋场渗滤液中抗生素及抗性基因污染特征研究，2020.1-2022.12，4万元，在研，主持

5.2018横向项目：太原市生活垃圾卫生填埋场渗滤液对周边环境影响研究，2018.1-2021.12. 4.5万元，在研，主持

6.2017横向项目：太原市大气细颗粒物采样及毒理分析，2017.9-2020.9. 4.6万元，在研，结题

7.2017年山西省百人计划项目，2017.7-2022.7,50万元，在研，主持

8.国家自然科学基金项目：大气细颗粒物毒性组分甄别研究(No. 91843301)，2019.12-2021.12，50万元，在研，参加

9.国家自然科学基金重点项目：太原和广州市大气细颗粒物诱导呼吸系统疾病的质谱代谢组学研究（No. 91543202），2016.1-2019.12，65万元，结题，参加

10.国务院及其他部委项目：山西调查地区居民环境金属总暴露调查（一期）（No. 2111101），2018.7-2019.2，50万元，在研，参加

11.2016横向项目：太原市生活垃圾卫生填埋场渗滤液采样分析，2016.9-2019.12. 8.1万元，主持，结题

12.2016年省级配套国家科研项目经费，2017.1-2018.12，20万元，主持，结题

13.山西省科技厅项目：灰霾天气PM2.5硝基多环芳烃污染特征及毒理学效应研究(No. 2014110)，2015.1-2016.12，4万元，主持，结题

14.山西省自然科学基金项目：山西省大气细颗粒物硝基多环芳烃污染特征及毒理和健康效应研究（No. 2014011036-2），2014.1-2016.12，3万元，主持，结题

15.山西省回国留学人员科研项目：细颗粒物和SO2诱导呼吸系统炎症的分子机制研究（No. 2013-016）2013.7-2015.12，5 万元，主持，结题

16.国家火炬计划项目：低品位盐湖钾矿高效开采与加工（No. 2013140104000015）2012/1-2014/1，27.9 万元，主持，结题

17.镉对溪蟹组织氧化损伤和钙稳态的影响及壳聚糖的预防效应，2010年中国博士后科学基金面上项目（No. 20100471580），主持，3万元 结题

18.P16作为生物标记研究杂环胺对大鼠胃的早期损伤，山西省自然科学基金（No. 2009011039-1），主持，2009.1-2011.12，5万元，结题

三、获奖

1. 2019年度山西省科学技术奖（自然科学奖）二等奖（2019-Z-014），排名第四，获奖人名单：张全喜，杨振华，李君灵，李瑞金，孟紫强，项目名称：大气主要污染物二氧化硫和沙尘暴颗粒物对呼吸和心血管系统的毒理效应，2021年3月

2. 2018年度山西省科学技术奖（自然科学奖）三等奖（2018-Z-006），排名第一，获奖人名单：李瑞金，董川，蔡宗苇，解静芳，耿红，项目名称：太原市大气细颗粒物污染特征及毒理学效应研究，2019年11月

3. 2019年度山西省高等学校优秀成果奖（科学技术）二等奖（2019KJ003），排名第一，获奖人名单：李瑞金，董川，蔡宗苇，解静芳，耿红，项目名称：太原市大气细颗粒物污染特征及毒理学效应研究，2019年7月

4. 2009年获得山西省科技进步一等奖（排名第五，获奖人名单为：孟紫强、解静芳、张波、刘晓莉、李瑞金、张全喜），项目名称：典型大气污染物毒理作用的系列研究。

5. 2008年8月获得山西省高等学校科技进步一等奖（排名第五，获奖人名单为：孟紫强、解静芳、张波、刘晓莉、李瑞金），项目名称：典型大气污染物毒理作用的系列研究。

6. 中国环境科学学会第十届优秀环境科技工作者奖,2014.12, 个人奖

四、专著

1. 孟紫强,郭新彪,郝卫东,马爱国,张志红,李瑞金,白剑英,张全喜,刘汝涛,安艳, 郭掌珍. 环境毒理学（第三版）, 北京：高教出版社, 53万字, 2018.11.1

2. 孟紫强，张全喜，李瑞金，杨振华，世界毒物全史第55卷环境毒理学史，西安：西北大学出版社，1.25万字，2016年12月

3. 孟紫强，张全喜，李瑞金，张义贤. 现代环境毒理学，中国环境出版社，146.6 万字，2015年12月

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